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Due to the net zero charge of acetyl-hexapeptide-3 at the applied pH, the electroosmosis was considered as the main permeation enhancement mechanism

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Based on the observation that Keap1 functions as a homodimer, the heterozygous missense mutation generates three types of Keap1 dimers, i.e., wild-type homodimer, wild-type-mutant heterodimer, and mutant homodimer at a ratio of 1:2:1